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Grafted kidney may be rejected in a patient due to:

1. Cell-mediated immune response
2. Passive immune response
3. Innate immune response
4. Humoral immune response

Correct answer: Cell-mediated immune response

Solution

Graft rejection is classically a T-cell–mediated process, where recipient T cells recognize donor antigens and damage the transplanted kidney. This is the main mechanism of acute cellular rejection.

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