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Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?

1. Chromosomes will be fragmented
2. Chromosomes will not segregate
3. Recombination of chromosome arms will occur
4. Chromosomes will not condense

Correct answer: Chromosomes will not segregate

Solution

APC promotes progression into anaphase by targeting key regulators for degradation, which allows sister chromatids to separate. If APC is defective, the cell cannot properly initiate chromatid separation, so chromosomes will not segregate.

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