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In cell cycle, DNA replication takes place in

1. G1 phase
2. G2 phase
3. Mitotic metaphase
4. S phase

Correct answer: S phase

Solution

DNA replication occurs during the synthesis (S) phase of interphase, when the cell duplicates its genetic material in preparation for cell division. G1 is growth, G2 is preparation for mitosis, and metaphase is a mitotic stage after replication is complete.

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