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At what stage of the cell cycle are histone proteins synthesized in a eukaryotic cell?

1. During G2 stage of prophase
2. During S-phase
3. During entire prophase
4. During telophase

Correct answer: During S-phase

Solution

Histone proteins are synthesized during S-phase because DNA replication occurs then, and the newly made DNA must be immediately packaged into nucleosomes. This timing ensures histones are available in step with DNA synthesis.

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