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Steroid hormones pass through the plasma membrane of a target cell and adhere to intracellular receptors residing in the cytoplasm or in the nucleus. In the nucleus, the hormone-receptor complex binds to a DNA sequence, called a hormone response element, which triggers gene transcription and translation.

1. Intracellular receptors are located in the cytoplasm of the cell and are activated by hydrophobic ligand molecules that can pass through the plasma membrane.
2. Cell-surface receptors bind to an external ligand molecule and convert an extracellular signal into an intracellular signal.

Correct answer: Intracellular receptors are located in the cytoplasm of the cell and are activated by hydrophobic ligand molecules that can pass through the plasma membrane.

Solution

Steroid hormones can pass through the plasma membrane and bind to intracellular receptors, which are located in the cytoplasm or nucleus.

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