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Which of the following substances, if introduced into the bloodstream, would cause coagulation of blood at the site of its introduction?

1. Fibrinogen
2. Prothrombin
3. Heparin
4. Thromboplastin

Correct answer: Thromboplastin

Solution

Thromboplastin (tissue factor) initiates the clotting cascade by activating prothrombin to thrombin, which then converts fibrinogen to fibrin. That local fibrin mesh causes coagulation at the site of introduction.

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