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Who proposed cAMP mediated 'Cascade model' of enzyme regulation?

1. Fischer
2. Sutherland
3. Sumner
4. Koshland

Correct answer: Sutherland

Solution

Earl Sutherland proposed the cAMP-mediated cascade model of enzyme regulation. He showed that cAMP acts as a second messenger in signal transduction, amplifying hormonal effects inside cells.

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