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Aspirin is produced by the acetylation of which of the following compounds?

1. m-Hydroxybenzoic acid
2. o-Dihydroxybenzene
3. o-Hydroxybenzoic acid
4. p-Dihydroxybenzene

Correct answer: o-Hydroxybenzoic acid

Solution

Aspirin (acetylsalicylic acid) is made by acetylating the phenolic -OH of salicylic acid, which is o-hydroxybenzoic acid.

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