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Regarding drug-enzyme interactions, identify the incorrect statement.

1. A non-competitive inhibitor binds to the allosteric site.
2. An allosteric inhibitor alters the shape of the enzyme's active site.
3. An allosteric inhibitor competes for the enzyme's active site.
4. A competitive inhibitor binds to the enzyme's active site.

Correct answer: An allosteric inhibitor competes for the enzyme's active site.

Solution

Allosteric/non-competitive inhibitors bind to a site other than the active site (the allosteric site) and change the active site's shape; they do not compete with substrate for the active site. Hence the statement that an allosteric inhibitor competes for the active site is incorrect.

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