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ExamsJEE AdvancedChemistry

Consider two statements about drug-enzyme interactions. Statement I: An enzyme's action can be blocked only if an inhibitor binds at the active site of the enzyme. Statement II: An inhibitor may form a strong covalent bond with the enzyme. Which option is correct?

  1. Both Statement I and Statement II are true
  2. Both Statement I and Statement II are false
  3. Statement I is true but Statement II is false
  4. Statement I is false but Statement II is true

Correct answer: Statement I is false but Statement II is true

Solution

Statement I is false because inhibitors can also bind at allosteric sites (not only the active site). Statement II is true since some inhibitors bind covalently and irreversibly.

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